Plenge Lab
Date posted: August 24, 2013 | Author: | Comments Off on Human genetics for target validation in drug discovery


Validating therapeutic targets through human genetics, Robert M. Plenge, Edward M. Scolnick and David Altshuler. Nature Reviews Drug Discovery. 2013 Aug;12(8):581-94. doi: 10.1038/nrd4051. Epub 2013 Jul 19. PMID: 23868113

We describe a strategy to use human genetics as a powerful tool to validate therapeutic targets for drug discovery.  We frame the concept of “genotype-phenotype dose-response curves”.

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